Research Topics

• Mechanisms of hapten-protein interactions

• Synthesis of ¹³C and ²H labelled molecules
• NMR identification of protein modifications using labelled molecules
• Synthesis of allylic hydroperoxides derived from terpenes (15-hydroperoxiabietic acid)
• Studies of radical interactions between haptens and proteins
• Synthesis of optically active natural compounds using assymmetric induction or chiral synthons

• Photoreactive molecules of dermatological interest

• Synthesis of psoralen derivatives
• Synthesis of new photoactivable molecules derived from lactones
• Photoreactivity studies of these molecules in solution or toward oligonucleotides
• NMR characterisation of formed photo-adducts

• Alternative non biological methods in immunotoxicology

• Quantitative structure activity relationships in allergic contact dermatitis
• Modelling of allergy using physico-chemical parameters